Chitin and chitosan in selected biomedical applications

Anitha, A., Sowmya, S., Sudheesh Kumar, P. T., Deepathi, S., Chennazhi, K. P., Ehrlich, H., Tsurkan, M. and Jayakumar, R. (2014) Chitin and chitosan in selected biomedical applications. Progress in Polymer Science, 39 9: 1644-1667. doi:10.1016/j.progpolymsci.2014.02.008

Author Anitha, A.
Sowmya, S.
Sudheesh Kumar, P. T.
Deepathi, S.
Chennazhi, K. P.
Ehrlich, H.
Tsurkan, M.
Jayakumar, R.
Title Chitin and chitosan in selected biomedical applications
Journal name Progress in Polymer Science   Check publisher's open access policy
ISSN 0079-6700
Publication date 2014-09
Sub-type Article (original research)
DOI 10.1016/j.progpolymsci.2014.02.008
Open Access Status
Volume 39
Issue 9
Start page 1644
End page 1667
Total pages 24
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Abstract Chitin (CT), the well-known natural biopolymer and chitosan (CS) (bio-based or "artificial polymer") are non-toxic, biodegradable and biocompatible in nature. The advantages of these biomaterials are such that, they can be easily processed into different forms such as membranes, sponges, gels, scaffolds, microparticles, nanoparticles and nanofibers for a variety of biomedical applications such as drug delivery, gene therapy, tissue engineering and wound healing. Present review focuses on the diverse applications of CT and CS membranes and scaffolds for drug delivery, tissue engineering and targeted regenerative medicine. The chitinous scaffolds of marine sponges' origin are discussed here for the first time. These CT based scaffolds obtained from Porifera possess remarkable and unique properties such as hydration, interconnected channels and diverse structural architecture. This review will provide a brief overview of CT and CS membranes and scaffolds toward different kinds of delivery applications such as anticancer drug delivery, osteogenic drug delivery, and growth factor delivery, because of their inimitable release behavior, degradation profile, mucoadhesive nature, etc. The review also provides an overview of the key features of CT and CS membranes and scaffolds such as their biodegradability, cytocompatibility and mechanical properties toward applications in tissue engineering and wound healing.
Keyword Chitin
Drug delivery
Growth factor delivery
Tissue engineering
Wound healing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Feb 2015, 11:51:33 EST by Anitha Sudheesh Kumar on behalf of School of Chemistry & Molecular Biosciences