Friends or foes: IL-10 and TGF-beta in melanoma

Tikoo, Shweta and Haass, Nikolas K. (2015) Friends or foes: IL-10 and TGF-beta in melanoma. Experimental Dermatology, 24 4: 254-255. doi:10.1111/exd.12661


Author Tikoo, Shweta
Haass, Nikolas K.
Title Friends or foes: IL-10 and TGF-beta in melanoma
Formatted title
Friends or foes: IL-10 and TGF-β in melanoma
Journal name Experimental Dermatology   Check publisher's open access policy
ISSN 0906-6705
1600-0625
Publication date 2015-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/exd.12661
Volume 24
Issue 4
Start page 254
End page 255
Total pages 2
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Melanoma is a highly immunogenic cancer associated with massive immune cell infiltration. The high immunogenicity of melanoma is attributed to melanoma antigens like MART-1 (melanoma antigen recognized by T cells-1), gp100, gp75 and tyrosinase (1). In spite of the heightened immune response to melanoma cell antigens, spontaneous immune-mediated regression of the disease is rare. The intractability of melanoma has often been associated with the immunosuppressive tumor milieu and the activation of immune checkpoints like CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and PD-1 (Programmed cell death 1). CTLA-4 and/or PD-1 (or its ligand, PD-L1) act as immune checkpoints by mediating reduction in the cytotoxic activity of cytotoxic T lymphocytes (CTLs) thus leading to immune exhaustion. CTLA-4 mediates T cell anergy by attenuating CD28 signaling or inducing cell cycle blockade. PD-1 on the other hand attenuates the antigen-specific signals thus inducing T cell unresponsiveness (2).
Keyword Melanoma
Immunosuppression
IL-10
TGF-β
Immune checkpoint
TGF-beta
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Feb 2015, 08:53:43 EST by Nikolas Haass on behalf of UQ Diamantina Institute