Should we consider introducing systematic screening for Lynch Syndrome?

Frayling, Ian and Ward, Robyn (2014) Should we consider introducing systematic screening for Lynch Syndrome?. Cancer Forum, 38 3: 187-190.

Author Frayling, Ian
Ward, Robyn
Title Should we consider introducing systematic screening for Lynch Syndrome?
Journal name Cancer Forum   Check publisher's open access policy
ISSN 0311-306X
Publication date 2014-11-01
Sub-type Critical review of research, literature review, critical commentary
Volume 38
Issue 3
Start page 187
End page 190
Total pages 4
Place of publication Sydney, NSW, Australia
Publisher Cancer Council Australia
Language eng
Subject 1306 Cancer Research
2730 Oncology
Formatted abstract
Lynch Syndrome is characterised by the development of colorectal, endometrial and other cancers, often at a young age. It is caused by constitutional mutations of DNA mismatch repair genes and cancers that arise in this setting are mismatch repair deficient, as demonstrated by loss of the relevant mismatch repair protein and microsatellite instability. In theory, universal screening of all index colorectal cancers for mismatch repair deficient should identify individuals who are at higher than population risk of carrying a constitutional mutation in the mismatch repair genes. A health economic evaluation in the UK found that this type of screening strategy applied to individuals under the age of 51 years was highly cost effective. In Australia, some centres routinely test all colorectal cancer for mismatch repair deficient, however there is currently no systematic national approach to screening. Given the cost effectiveness of universal screening is dependent on uptake of constitutional testing by the index case and their relatives, we suggest that research into the determinants and barriers to uptake of constitutional testing is a high priority. Further, given that the health care context can influence the assessment of cost-effectiveness, we propose that the UK economic evaluation also needs to be undertaken in an Australian context.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Office of the Vice-Chancellor
 
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