Cytokine-Mediated Induction of HLA Antigen Expression on Human Glomerular Mesangial Cells

Hawkins, NJ, Ward, RL and Wakefield, D (1994) Cytokine-Mediated Induction of HLA Antigen Expression on Human Glomerular Mesangial Cells. Cellular Immunology, 155 2: 493-500. doi:10.1006/cimm.1994.1141


Author Hawkins, NJ
Ward, RL
Wakefield, D
Title Cytokine-Mediated Induction of HLA Antigen Expression on Human Glomerular Mesangial Cells
Journal name Cellular Immunology   Check publisher's open access policy
ISSN 0008-8749
Publication date 1994
Sub-type Article (original research)
DOI 10.1006/cimm.1994.1141
Volume 155
Issue 2
Start page 493
End page 500
Total pages 8
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract Well-characterized human glomerular mesangial cells were stimulated in vitro with interferon-γ (IFN-γ), interleukin-1, and tumor necrosis factor α (TNF-α) to determine the influence of these cytokines on the expression of class I and II HLA antigens. IFN-γ induced a dose-dependent increase in expression of both class I and class II HLA antigens. TNF-α induced only class I antigens when used alone, but acted synergistically with IFN-γ in the expression of class I and II antigens. Interleukin-1 had little effect on HLA antigen expression. These results raise the possibility that stimulated mesangial cells may act as antigen-presenting cells and may mediate local immune reactions in the glomerulus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Wed, 11 Feb 2015, 13:16:01 EST by Ms Kate Rowe