5-Hydroxytryptamine depletion with para-chlorophenylalanine: Effects on eating, drinking, irritability, muricide, and copulation

Paxinos, G, Burt, J, Atrens, DM and Jackson, DM (1977) 5-Hydroxytryptamine depletion with para-chlorophenylalanine: Effects on eating, drinking, irritability, muricide, and copulation. Pharmacology, Biochemistry and Behavior, 6 4: 439-447. doi:10.1016/0091-3057(77)90182-4


Author Paxinos, G
Burt, J
Atrens, DM
Jackson, DM
Title 5-Hydroxytryptamine depletion with para-chlorophenylalanine: Effects on eating, drinking, irritability, muricide, and copulation
Journal name Pharmacology, Biochemistry and Behavior   Check publisher's open access policy
ISSN 0091-3057
Publication date 1977
Sub-type Article (original research)
DOI 10.1016/0091-3057(77)90182-4
Volume 6
Issue 4
Start page 439
End page 447
Total pages 9
Language eng
Subject 1303 Specialist Studies in Education
2802 Behavioral Neuroscience
3004 Pharmacology
Abstract Forty-four male rats were tested for eating, drinking, irritability, and copulation before and after intraperitonial para-chlorophenylalanine (PCPA) or control injections. Eleven of these rats were tested for muricide before and after PCPA injections (Group 1), while 18 others were tested only after PCPA injections (Groups 2). Groups 1 rats received four 350 mg/kg PCPA injections spaced 6 days apart and showed hyperdipsia, weight loss, and a 24% increase in muricide. Group 2 rats received five daily 100 mg/kg PCPA injections repeated 11 days later and showed hyperdipsia and weight loss; in addition, 78% of them killed mice. Neither group showed significant changes in copulation. At the end of the experiment, 6 rats from Group 2 that were irritable and killed mice were injected intraperitonially with 5-hydroxytryptophan (80 mg/kg). Five of these rats lost their irritability and four stopped killing. The various behavioral changes were not correlated significantly either with each other or with the degree of 5-hydroxytryptamine depletion. This tentatively suggests that PCPA may produce its effects on behavior by other means in addition to 5-hydroxytryptamine depletion.
Keyword 5-Hydroxtryptophan
5-Hydroxytryptamine
Copulation
Drinking
Eating
Irritability
Muricide
Para-chlorophenylalanine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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