Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer

Liu, Jia (Jenny) and Ward, Robyn Lynne (2010). Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer. In Zdenko Herceg and Toshikazu Ushijima (Ed.), Epigenetics and Cancer Part B (pp. 79-121) Amsterdam, The Netherlands: Elsevier. doi:10.1016/B978-0-12-380864-6.00004-3


Author Liu, Jia (Jenny)
Ward, Robyn Lynne
Title of chapter Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer
Title of book Epigenetics and Cancer Part B
Place of Publication Amsterdam, The Netherlands
Publisher Elsevier
Publication Year 2010
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-380864-6.00004-3
Open Access Status
Series Advances in genetics
ISBN 978-0-12-380864-6
ISSN 0065-2660
Editor Zdenko Herceg
Toshikazu Ushijima
Volume number 71
Chapter number 4
Start page 79
End page 121
Total pages 43
Total chapters 9
Language eng
Formatted Abstract/Summary
Folate is a methyl donor that plays an essential role in DNA synthesis and biological methylation reactions, including DNA methylation. Folate deficiency may be implicated in the development of genomic DNA hypomethylation, which is an early epigenetic event found in many cancers, particularly colorectal cancer (CRC). Numerous studies employing in vitro systems, animal models, and human interventional studies have tested this hypothesis. Here, we describe the role of folate as a methyl donor in the one-carbon metabolism cycle, and the consequences of cellular folate deficiency. The existing evidence on folate and its relationship to DNA methylation is discussed using CRC as an example. While there remain numerous technical challenges in this important field of research, changes to folate intake appear to be capable of modulating DNA methylation levels in the human colonic mucosa and this may potentially alter CRC risk.
Keyword Folic-acid supplementation
Neural-tube defects
Colonic mucosal concentrations
Folate/methyl-deficient rats
Spina-Bifida pregnancy
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: Office of the Vice-Chancellor
 
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Created: Wed, 11 Feb 2015, 09:17:50 EST by Ms Kate Rowe on behalf of Office of Deputy Vice-Chancellor (Research)