Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation

Klyne, David M., Schmid, Annina B., Moseley, G. Lorimer, Sterling, Michele and Hodges Paul W. (2015) Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation. Journal of Pain, 16 2: 176-185. doi:10.1016/j.jpain.2014.11.005

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Author Klyne, David M.
Schmid, Annina B.
Moseley, G. Lorimer
Sterling, Michele
Hodges Paul W.
Title Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation
Journal name Journal of Pain   Check publisher's open access policy
ISSN 1526-5900
Publication date 2015-02
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jpain.2014.11.005
Open Access Status
Volume 16
Issue 2
Start page 176
End page 185
Total pages 10
Place of publication Philadelphia PA, United States
Publisher Churchill Livingstone
Collection year 2015
Language eng
Abstract Reduced pain perception during painful stimulation to another body region (ie, conditioned pain modulation [CPM]) is considered important for pain modulation and development of pain disorders. The various methods used to study CPM limit comparison of findings. We investigated the influence of key methodologic variations on CPM and the properties of CPM when the back is used for the test stimulus or the conditioning stimulus (CS). Two different test stimuli (pressure pain threshold and pain response to suprathreshold heat [Pain-45, ie, pain rated at 45 on a 0–100 numeric rating scale]) were assessed before and during application of a noxious or non-noxious (sham) CS. Eight blocks of trials varied the anatomic location (back and forearms) and arrangement (body side) of the stimuli. Pressure pain threshold (as the test stimulus) increased during application of noxious, but not non-noxious, CS when stimuli were applied to opposite body sides or heterotopic sites on one body side. Inconsistent with pain-induced CPM, Pain-45 decreased during both noxious and non-noxious CS. These findings indicate that 1) pressure pain threshold can be more confidently interpreted with respect to CPM evoked by a painful stimulus than Pain-45, 2) the back and forearm are equally effective as sites for stimuli, and 3) stimuli arrangement does not influence CPM, except for identical anatomic regions on the same body side.
Keyword Conditioned pain modulation
Pain modulation
Pain threshold
Suprathreshold pain
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 15 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Tue, 10 Feb 2015, 23:01:15 EST by Ms Annina Barbara Schmid on behalf of School of Health & Rehabilitation Sciences