The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies

Morgan, G, Ward, R and Barton, M (2004) The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clinical Oncology, 16 8: 549-560. doi:10.1016/j.clon.2004.06.007

Author Morgan, G
Ward, R
Barton, M
Title The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies
Journal name Clinical Oncology   Check publisher's open access policy
ISSN 0936-6555
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.clon.2004.06.007
Volume 16
Issue 8
Start page 549
End page 560
Total pages 12
Language eng
Subject 2730 Oncology
2741 Radiology Nuclear Medicine and imaging
Abstract Aims: The debate on the funding and availability of cytotoxic drugs raises questions about the contribution of curative or adjuvant cytotoxic chemotherapy to survival in adult cancer patients. Materials and methods: We undertook a literature search for randomised clinical trials reporting a 5-year survival benefit attributable solely to cytotoxic chemotherapy in adult malignancies. The total number of newly diagnosed cancer patients for 22 major adult malignancies was determined from cancer registry data in Australia and from the Surveillance Epidemiology and End Results data in the USA for 1998. For each malignancy, the absolute number to benefit was the product of (a) the total number of persons with that malignancy; (b) the proportion or subgroup(s) of that malignancy showing a benefit; and (c) the percentage increase in 5-year survival due solely to cytotoxic chemotherapy. The overall contribution was the sum total of the absolute numbers showing a 5-year survival benefit expressed as a percentage of the total number for the 22 malignancies. Results: The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA. Conclusion: As the 5-year relative survival rate for cancer in Australia is now over 60%, it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.
Keyword Chemotherapy
Combined modality treatment
Quality of life
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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