Second primary colorectal cancers (SPCRCs): experiences from a large Australian cancer registry

Ringland, C. L., Arkenau, H. -T., O'Connell, D. L. and Ward, R. L. (2010) Second primary colorectal cancers (SPCRCs): experiences from a large Australian cancer registry. Annals of Oncology, 21 1: 92-97. doi:10.1093/annonc/mdp288


Author Ringland, C. L.
Arkenau, H. -T.
O'Connell, D. L.
Ward, R. L.
Title Second primary colorectal cancers (SPCRCs): experiences from a large Australian cancer registry
Journal name Annals of Oncology   Check publisher's open access policy
ISSN 0923-7534
1569-8041
Publication date 2010-01
Year available 2009
Sub-type Article (original research)
DOI 10.1093/annonc/mdp288
Open Access Status Not Open Access
Volume 21
Issue 1
Start page 92
End page 97
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background:  We examined the rate of second primary colorectal cancer (SPCRC) in a cohort of 29 471 patients first diagnosed with colorectal cancer (CRC) from 1987 to 1996, in New South Wales (NSW), Australia.

Methods:  
The 5-year age group, date and site of first and subsequent CRC diagnoses as well as death dates were obtained from the NSW Central Cancer Registry. The time to SPCRC and standardised incidence ratios (SIRs) were generated.

Results:  Six hundred and sixty patients (2.1%) developed SPCRCs and the cumulative incidence at 18 years was 5.5%, 95% confidence interval (CI) 4.9% to 6.3%. The risk of SPCRC was increased in patients with a CRC history compared with the general population (SIR = 1.5, 95% CI 1.4-1.6) and inversely related to age at first diagnosis (30-49 years, SIR = 5.1, 95% CI 3.6-7.1 versus ≥80 years, SIR = 1.1, 95% CI 0.9-1.4). The excess absolute risk of SPCRC was greater for females aged 50-69 years at first diagnosis than for males in the same age group. SPCRC was also increased in individuals with right-sided first primaries (SIR = 2.0, 95% CI 1.6-2.4).

Conclusions:  The SPCRC rate was increased during the first 5 years after first diagnosis but remained increased for up to 10 years in females, in patients with right-sided cancers and in patients <60 years at first diagnosis. These findings support active surveillance up to 10 years in these risk groups.
Keyword Cancer registry
Colorectal cancer
Secondary primary colorectal cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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