Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines

Yip, Yum L. and Ward, Robyn L. (2002) Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines. Cancer Immunology, Immunotherapy, 50 11: 569-587. doi:10.1007/s002620100226

Author Yip, Yum L.
Ward, Robyn L.
Title Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines
Journal name Cancer Immunology, Immunotherapy   Check publisher's open access policy
ISSN 0340-7004
Publication date 2002-01
Year available 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s002620100226
Open Access Status Not yet assessed
Volume 50
Issue 11
Start page 569
End page 587
Total pages 19
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract The tumour antigen ErbB-2 belongs to the epidermal growth factor receptor family. Numerous studies have shown that ErbB-2 is overexpressed in many cancers and it is prognostically important in a subset of malignancies. It is well recognised that this receptor has many characteristics that make it an excellent target for tumour-specific immunotherapy. One anti-ErbB-2 monoclonal antibody, Herceptin or TrastuzuMab, has already shown clinical efficacy for the treatment of metastatic breast cancer. However, despite this success, it is still currently unclear how monoclonal antibodies inhibit tumour growth in vivo. This review will summarise the biological activities of a range of anti-ErbB-2 Mabs, as well as their possible mechanisms of action. In addition, as an active mode of immunotherapy, the current vaccine strategies for inducing or enhancing ErbB-2-specific immunity will also be discussed. It is anticipated that a better understanding of the activities of anti-ErbB-2 Mabs will aid in the development of both passive and active immunotherapies against this important receptor.
Keyword Anti-ErbB-2 monoclonal antibodies
Immune responses
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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