The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis

Ford, Caroline E., Ma, Sean Si Qian, Quadir, Ashfaque and Ward, Robyn L. (2013) The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis. International Journal of Cancer, 133 4: 779-787. doi:10.1002/ijc.27984


Author Ford, Caroline E.
Ma, Sean Si Qian
Quadir, Ashfaque
Ward, Robyn L.
Title The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
1097-0215
Publication date 2013-08-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ijc.27984
Open Access Status Not Open Access
Volume 133
Issue 4
Start page 779
End page 787
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been disappointing to date. The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type. This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field. Copyright
Keyword β-catenin
cancer
metastasis
ROR2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Office of the Vice-Chancellor
 
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