Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study

Umeda, Satoshi, Harrison, Neil A, Gray, Marcus A, Mathias, Christopher J and Critchley, Hugo D (2015) Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study. Frontiers in Neuroscience, 9 MAR: . doi:10.3389/fnins.2015.00034

Author Umeda, Satoshi
Harrison, Neil A
Gray, Marcus A
Mathias, Christopher J
Critchley, Hugo D
Title Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study
Journal name Frontiers in Neuroscience   Check publisher's open access policy
ISSN 1662-453X
Publication date 2015-03-17
Year available 2015
Sub-type Article (original research)
DOI 10.3389/fnins.2015.00034
Open Access Status DOI
Volume 9
Issue MAR
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2016
Language eng
Abstract Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5–10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.
Keyword Autonomic disorders
Postural tachycardia syndrome
Salience network
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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