Quantitative analysis of iris changes following mydriasis in subjects with different mechanisms of angle closure

Zhang, Ye, Li, Si Zhen, Li, Lei, He, Ming Guang, Thomas, Ravi and Wang, Ning Li (2015) Quantitative analysis of iris changes following mydriasis in subjects with different mechanisms of angle closure. Investigative Ophthalmology and Visual Science, 56 1: 563-570. doi:10.1167/iovs.14-15216


Author Zhang, Ye
Li, Si Zhen
Li, Lei
He, Ming Guang
Thomas, Ravi
Wang, Ning Li
Title Quantitative analysis of iris changes following mydriasis in subjects with different mechanisms of angle closure
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 1552-5783
0146-0404
Publication date 2015-01
Year available 2015
Sub-type Article (original research)
DOI 10.1167/iovs.14-15216
Volume 56
Issue 1
Start page 563
End page 570
Total pages 8
Place of publication Rockville, United States
Publisher Association for Research in Vision and Ophthalmology
Collection year 2016
Language eng
Formatted abstract
Purpose. We estimate and compare change in iris cross-sectional area (IA) after physiologic and pharmacologic mydriasis in subjects with different dominant mechanisms for primary angle closure.

Methods. Anterior segment optical coherence tomography (AS-OCT) measurements in light, dark, and following pharmacologic dilation were obtained on primary angle closure suspects (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG) examined during the 5-year follow-up of the Handan Eye Study. Subjects were categorized into three subgroups according to their dominant angle closure (AC) mechanisms as determined by AS-OCT: pupillary block (PB), plateau iris configuration (PIC), and thick peripheral iris roll (TPIR). The IA and other biometric parameters measured using the Zhongshan Angle Assessment Program in the right eyes of all subjects were analyzed.

Results. A total of 364 right eyes of subjects with PACS (333), and PAC/PACG (31) was included in the analysis. Significant differences in the change of IAs (P = 0.030), IA loss per mm pupil diameter (PD) increase (P = 0.001) in light versus pharmacologic dilation, and IA loss per mm PD increase (P = 0.011) from dark versus pharmacologic dilation were observed among the three groups. The smallest decrease occurred in the PB group.

Conclusions. There are significant differences in IA and IA loss per mm of pupil change following physiologic or pharmacologic mydriasis in Chinese subjects with dissimilar dominant mechanisms for AC. Dynamic iris change may have a more important role in angle closure where PB is the dominant mechanism.
Keyword Angle closure mechanism
Anterior segment optical coherence tomography
Iris cross-sectional area
Primary angle closure disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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