Neuromodulatory treatments for chronic pain: Efficacy and mechanisms

Jensen, Mark P., Day, Melissa A. and Miro, Jordi (2014) Neuromodulatory treatments for chronic pain: Efficacy and mechanisms. Nature Reviews Neurology, 10 3: 167-178. doi:10.1038/nrneurol.2014.12

Author Jensen, Mark P.
Day, Melissa A.
Miro, Jordi
Title Neuromodulatory treatments for chronic pain: Efficacy and mechanisms
Journal name Nature Reviews Neurology   Check publisher's open access policy
ISSN 1759-4766
Publication date 2014-03
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrneurol.2014.12
Open Access Status
Volume 10
Issue 3
Start page 167
End page 178
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Chronic pain is common, and the available treatments do not provide adequate relief for most patients. Neuromodulatory interventions that modify brain processes underlying the experience of pain have the potential to provide substantial relief for some of these patients. The purpose of this Review is to summarize the state of knowledge regarding the efficacy and mechanisms of noninvasive neuromodulatory treatments for chronic pain. The findings provide support for the efficacy and positive side-effect profile of hypnosis, and limited evidence for the potential efficacy of meditation training, noninvasive electrical stimulation procedures, and neurofeedback procedures. Mechanisms research indicates that hypnosis influences multiple neurophysiological processes involved in the experience of pain. Evidence also indicates that mindfulness meditation has both immediate and long-term effects on cortical structures and activity involved in attention, emotional responding and pain. Less is known about the mechanisms of other neuromodulatory treatments. On the basis of the data discussed in this Review, training in the use of self-hypnosis might be considered a viable 'first-line' approach to treat chronic pain. More-definitive research regarding the benefits and costs of meditation training, noninvasive brain stimulation and neurofeedback is needed before these treatments can be recommended for the treatment of chronic pain.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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