Silencing of E6/E7 expression in cervical cancer stem-like cells

Gu, Wenyi, McMillan, Nigel and Yu, Chengzhong (2015). Silencing of E6/E7 expression in cervical cancer stem-like cells. In Daniel Keppler and Athena W. Lin (Ed.), Cervical cancer: methods and protocols (pp. 173-182) New York, NY United States: Springer. doi:10.1007/978-1-4939-2013-6_12


Author Gu, Wenyi
McMillan, Nigel
Yu, Chengzhong
Title of chapter Silencing of E6/E7 expression in cervical cancer stem-like cells
Title of book Cervical cancer: methods and protocols
Place of Publication New York, NY United States
Publisher Springer
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4939-2013-6_12
Year available 2015
Series Methods in Molecular Biology
ISBN 9781493920129
9781493920136
ISSN 1064-3745
1940-6029
Editor Daniel Keppler
Athena W. Lin
Volume number 1249
Chapter number 12
Start page 173
End page 182
Total pages 10
Total chapters 29
Collection year 2016
Language eng
Formatted Abstract/Summary
Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.
Keyword Cancer stem cells
Gene silence
HPV E6/E7
RNAi
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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