Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation

Kimura, Masaki, Iida, Mayuko, Yamauchi, Hideki, Suzuki, Masato, Shibasaki, Toshiaki, Saito, Yoshimasa and Saito, Hidetsugu (2014) Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation. Journal of Functional Foods, 11 114-120. doi:10.1016/j.jff.2014.08.001


Author Kimura, Masaki
Iida, Mayuko
Yamauchi, Hideki
Suzuki, Masato
Shibasaki, Toshiaki
Saito, Yoshimasa
Saito, Hidetsugu
Title Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation
Journal name Journal of Functional Foods   Check publisher's open access policy
ISSN 1756-4646
2214-9414
Publication date 2014-11
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jff.2014.08.001
Open Access Status
Volume 11
Start page 114
End page 120
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract The effects of astaxanthin supplementation on visceral adipose tissue and lipid profile in an Otsuka Long Evans Tokushima Fatty (OLETF) rat model of hyperphagia and visceral fat accumulation was investigated. At 25 weeks of age, OLETF rats were assigned randomly to an obese control (OC, n = 6) or an astaxanthin supplementation (AX, n = 6) group. Long Evans Tokushima Otsuka (LETO) rats were assigned to a lean control (LT, n = 6) group. The AX group was subjected to 6 weeks of dietary supplementation with 0.2% astaxanthin (2 g/kg diet powder chow food) ad libitum. After the 6-week experimental period, astaxanthin supplementation in obese rats promoted size reduction of visceral adipocytes, with a remarkable decrease in FFA and a significant increase in blood HDL-c concentrations. These results suggest that astaxanthin can at least partially ameliorate lipid profile and adipocyte abnormalities associated with obesity.
Keyword Astaxanthin
Supplementation
Visceral fat
Adipocyte size
Lipid profile
Lipid oxidation
Oxidative stress
Metabolic syndrome
Adipose tissue
Obesity
Extract
Diet
Adiponectin
Carotenoids
Receptors
Increases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2015 Collection
 
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