Effect of menopausal status on carotid intima-media thickness and presence of carotid plaque in Chinese women generation population

Zhou, Yong, Wang, Dandan, Yang, Xin, Wang, Anxin, Gao, Xiang, Guo, Yuming, Wu, Shouling and Zhao, Xingquan (2015) Effect of menopausal status on carotid intima-media thickness and presence of carotid plaque in Chinese women generation population. Scientific Reports, 5 . doi:10.1038/srep08076


Author Zhou, Yong
Wang, Dandan
Yang, Xin
Wang, Anxin
Gao, Xiang
Guo, Yuming
Wu, Shouling
Zhao, Xingquan
Title Effect of menopausal status on carotid intima-media thickness and presence of carotid plaque in Chinese women generation population
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2015-01-28
Year available 2015
Sub-type Article (original research)
DOI 10.1038/srep08076
Open Access Status DOI
Volume 5
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability of carotid plaque in Chinese female population is unclear. We conducted a population-based, cross-sectional study by recruiting 2,131 participants aged above 40 years from northeast of China. Carotid intima-media thickness (CIMT), presence of carotid plaque and its stability were evaluated by carotid duplex sonography. Among the participants, 1,133 (53.2%) were identified to be postmenopausal. After adjusting for potential confounding factors, presence of CIMT at 50th- 75th and ≥75th percentiles, carotid plaque and its unstable status were found to be significantly associated with the postmenopausal status (P < 0.001). When matched the participants by age, post-menopausal status was still associated with a higher risk of having unstable plaque. Moreover, our data show that postmenopausal status is a risk factor for intracranial arterial stenosis when compared with premenopausal status in the univariate analysis (OR = 1.314, P = 0.043), and such relationship is lost when the confounding factors are adjusted (OR = 0.828, P = 0.225). In conclusion, the vascular risk factors increase as the menopausal status changes. Compared with premenopausal status, postmenopausal status is associated with higher morbidity of CIMT, carotid plaque and its unstable status.
Keyword Carotid artery disease
Epidemiology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number: 5:8076

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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Created: Tue, 03 Feb 2015, 11:55:06 EST by Yuming Guo on behalf of School of Public Health