In vitro adhesion of oral candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine

Ellepola, Arjuna N. B., Joseph, Bobby K., Altarakemah, Yacoub, Samaranayake, Lakshman P., Anil, Sukumaran, Hashem, Mohamed and Khan, Zia U. (2015) In vitro adhesion of oral candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine. Medical Principles and Practice, 24 1: 58-64. doi:10.1159/000369019


Author Ellepola, Arjuna N. B.
Joseph, Bobby K.
Altarakemah, Yacoub
Samaranayake, Lakshman P.
Anil, Sukumaran
Hashem, Mohamed
Khan, Zia U.
Title In vitro adhesion of oral candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine
Formatted title
In vitro adhesion of oral Candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine
Journal name Medical Principles and Practice   Check publisher's open access policy
ISSN 1423-0151
1011-7571
Publication date 2015-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1159/000369019
Open Access Status DOI
Volume 24
Issue 1
Start page 58
End page 64
Total pages 7
Place of publication Basel Switzerland
Publisher S. Karger AG
Collection year 2015
Language eng
Formatted abstract
Objectives: We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures. Methods: After determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay. Results: Compared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of C. dubliniensis isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p < 0.001 for all drugs), respectively. Conclusions: Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces.
Keyword Candida dubliniensis
Nystatin
Amphotericin B
Ketoconazole
Fluconazole
Chlorhexidine
Acrylic dentures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 29 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Dentistry Publications
 
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