Pharmacokinetic profiles of the analgesic drug flupirtine in cats

De Vito, V., Łebkowska-Wieruszewska, B., Owen, H., Kowalski, C. J. and Giorgi, M. (2014) Pharmacokinetic profiles of the analgesic drug flupirtine in cats. The Veterinary Journal, 202 2: 309-313. doi:10.1016/j.tvjl.2014.06.011

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Author De Vito, V.
Łebkowska-Wieruszewska, B.
Owen, H.
Kowalski, C. J.
Giorgi, M.
Title Pharmacokinetic profiles of the analgesic drug flupirtine in cats
Journal name The Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233
Publication date 2014-11
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2014.06.011
Open Access Status
Volume 202
Issue 2
Start page 309
End page 313
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic effects, used in the treatment of a wide range of pain states in human beings. There is a substantial body of evidence on the efficacy of FLU in humans but this is inadequate to recommend its off-label use in veterinary clinical practice. The aim of this study was to evaluate the pharmacokinetic profiles of FLU after IV and PO administration in healthy cats.

Six mixed breed adult cats were randomly assigned to two treatment groups using an open, single-dose, two-treatment, two-phase, paired, cross-over design (2 × 2 Latin-square). Group 1 (n  =  3) received a single dose of 5 mg/kg of FLU injected IV into the jugular vein. Group 2 (n  =  3) received the same dose via PO route. The wash out period was 1 week. Blood samples (1 mL) were collected at assigned times and plasma was then analysed by a validated HPLC method.

No adverse effects at the point of injection and no behavioural changes or alterations in health parameters were observed in the animals during or after the study (up to 7 days after the full study). After IV administration, FLU was detectable in plasma up to 36 h. After PO administration, FLU plasma concentrations were lower than those following IV administration, but they were detectable over the same time range. The terminal part of both mean pharmacokinetic curves showed a similar trend of elimination. The oral bioavailability was approximately 40%. This is the first study of FLU in an animal species of veterinary interest and it could pave the way for the use of this active ingredient in the veterinary field.
Keyword Cats
Pain reliever
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 02 Feb 2015, 16:44:46 EST by Dr Helen Owen on behalf of School of Veterinary Science