Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells

Taing, Meng-Wong, Pierson, Jean-Thomas, Shaw, Paul N., Dietzgen, Ralf G., Roberts-Thomson, Sarah J., Gidley, Michael J. and Monteith, Gregory R. (2015) Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells. Journal of Chemistry, 2015 613268.1-613268.10. doi:10.1155/2015/613268


Author Taing, Meng-Wong
Pierson, Jean-Thomas
Shaw, Paul N.
Dietzgen, Ralf G.
Roberts-Thomson, Sarah J.
Gidley, Michael J.
Monteith, Gregory R.
Title Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells
Journal name Journal of Chemistry   Check publisher's open access policy
ISSN 2090-9063
2090-9071
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.1155/2015/613268
Open Access Status DOI
Volume 2015
Start page 613268.1
End page 613268.10
Total pages 10
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2016
Language eng
Abstract The assessment of human cancer cell proliferation is a common approach in identifying plant extracts that have potential bioactive effects. In this study, we tested the hypothesis that methanolic extracts of peel and flesh from three archetypal mango cultivars, Irwin (IW), Nam Doc Mai (NDM), and Kensington Pride (KP), differentially affect proliferation, extracellular signal-regulated kinase (ERK) activity, and intracellular calcium ([Ca2+]I) signalling in MCF-7 human breast cancer cells. Mango flesh extracts from all three cultivars did not inhibit cell growth, and of the peel extracts only NDM reduced MCF-7 cell proliferation. Mango cultivar peel and flesh extracts did not significantly change ERK phosphorylation compared to controls; however, some reduced relative maximal peak [Ca2+]I after adenosine triphosphate stimulation, with NDM peel extract having the greatest effect among the treatments. Our results identify mango interfruit and intrafruit (peel and flesh) extract variability in antiproliferative effects and [Ca2+]I signalling in MCF-7 breast cancer cells and highlight that parts of the fruit (such as peel and flesh) and cultivar differences are important factors to consider when assessing potential chemopreventive bioactive compounds in plants extracts.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 29 Jan 2015, 23:57:04 EST by Mr Meng-wong Taing on behalf of School of Pharmacy