Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

Anitha, A., Deepa, N., Chennazhi, K. P., Nair, S.V., Tamura, H. and Jayakumar, R. (2011) Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications. Carbohydrate Polymers, 83 1: 66-73. doi:doi:10.1016/j.carbpol.2010.07.028

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Author Anitha, A.
Deepa, N.
Chennazhi, K. P.
Nair, S.V.
Tamura, H.
Jayakumar, R.
Title Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
Publication date 2011-01-01
Year available 2010
Sub-type Article (original research)
DOI doi:10.1016/j.carbpol.2010.07.028
Open Access Status File (Author Post-print)
Volume 83
Issue 1
Start page 66
End page 73
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
The main objective of this work was to develop nanoparticles (NPs) of a mucoadhesive polymer based on chitosan for biomedical applications. Here, we developed thiolated chitosan (TCS) using thioglycolic acid (TGA) and chitosan in the presence of 1-ethyl-3-3(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as catalyst. The prepared TCS was characterized using FT-IR and the degree of thiol substitution was found out by Ellman's method. The TCS nanoparticles (TCS-NPs) were developed using ionic cross-linking reaction with pentasodium tripolyphosphate (TPP). The prepared TCS-NPs were characterized by DLS, AFM, FT-IR, TG/DTA, etc. In vitro cytocompatibility and cell uptake studies were also carried out. These studies suggest that the prepared NPs show less toxicity towards normal and cancer cells and they are easily taken up by both the normal and cancer cells. So the prepared TCS-NPs could be used for drug and gene delivery applications.
Keyword Thiolated chitosan
Thermal studies
Drug delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 21 July 2010

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 27 Jan 2015, 16:37:56 EST by Anitha Sudheesh Kumar on behalf of School of Chemistry & Molecular Biosciences