Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications

Dev, Ashish, Binulal, N. S., Anitha, A., Nair, S. V., Furuike, T., Tamura, H. and Jayakumar, R. (2010) Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications. Carbohydrate Polymers, 80 3: 833-838. doi:10.1016/j.carbpol.2009.12.040

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Author Dev, Ashish
Binulal, N. S.
Anitha, A.
Nair, S. V.
Furuike, T.
Tamura, H.
Jayakumar, R.
Title Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
1879-1344
Publication date 2010-05-05
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.carbpol.2009.12.040
Open Access Status File (Author Post-print)
Volume 80
Issue 3
Start page 833
End page 838
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2011
Language eng
Formatted abstract
Poly(lactic acid) (PLA)/chitosan (CS) nanoparticles were prepared by emulsion method for anti-HIV drug delivery applications. The prepared PLA/CS nanoparticles were characterized using DLS, SEM, and FTIR. The hydrophilic antiretroviral drug Lamivudine was loaded into PLA/CS nanoparticles. The encapsulation efficiency and in-vitro drug release behaviour of drug loaded PLA/CS nanoparticles were studied using UV spectrophotometer. In addition, the cytotoxicity of the PLA/CS nanoparticles using MTT assay was also studied. The in-vitro drug release studies showed that drug release rate was lower in the acidic pH when compared to alkaline pH. This may due to repulsion between H+ ions and cationic groups present in the polymeric nanoparticles. Drug release rate was found to be higher in the 6% drug loaded formulation when compared to 3% drug loaded formulation. These results indicated that the PLA/CS nanoparticles are a promising carrier system for controlled delivery of anti-HIV drugs.
Keyword Polylactic Acid
Chitosan
Lamivudine drug
Emulsion
Nanoparticles
Controlled drug delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Tue, 27 Jan 2015, 16:33:16 EST by Anitha Sudheesh Kumar on behalf of School of Chemistry & Molecular Biosciences