Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Brun, Susana, Beaino, Wissam, Kremer, Laurent, Taleb, Omar, Mensah-Nyagan, Ayikoe Guy, Lam, Chanh D., Greer, Judith M., de Seze, Jerome and Trifilieff, Elisabeth (2015) Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies. Journal of Neuroimmunology, 278 1-10. doi:10.1016/j.jneuroim.2014.11.022


Author Brun, Susana
Beaino, Wissam
Kremer, Laurent
Taleb, Omar
Mensah-Nyagan, Ayikoe Guy
Lam, Chanh D.
Greer, Judith M.
de Seze, Jerome
Trifilieff, Elisabeth
Title Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 1872-8421
0165-5728
Publication date 2015-01-15
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2014.11.022
Open Access Status
Volume 278
Start page 1
End page 10
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180–199) peptide developed a chronic, sometimes relapsing–remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.
Keyword Animal model
Thiopalmitoylated P0 peptide
Chronic EAN
CIDP
Electrophysiology
Sciatic nerve immunohistochemistry
Immunology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 27 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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