Are caveolae a cellular entry route for non-viral therapeutic delivery systems?

Rewatkar, Prarthana V., Parton, Robert G., Parekh, Harendra S. and Parat, Marie-Odile (2015) Are caveolae a cellular entry route for non-viral therapeutic delivery systems?. Advanced Drug Delivery Reviews, 91 92-108. doi:10.1016/j.addr.2015.01.003


Author Rewatkar, Prarthana V.
Parton, Robert G.
Parekh, Harendra S.
Parat, Marie-Odile
Title Are caveolae a cellular entry route for non-viral therapeutic delivery systems?
Journal name Advanced Drug Delivery Reviews   Check publisher's open access policy
ISSN 1872-8294
0169-409X
Publication date 2015
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.addr.2015.01.003
Volume 91
Start page 92
End page 108
Total pages 17
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract The development of novel therapies increasingly relies on sophisticated delivery systems that allow the drug or gene expression-modifying agent of interest entry into cells. These systems can promote cellular targeting and/or entry, and they vary in size, charge, and functional group chemistry. Their optimization requires an in depth knowledge of the cellular routes of entry in normal and pathological states. Caveolae are plasma membrane invaginations that have the potential to undergo endocytosis. We critically review the literature exploring whether drug or nucleic acid delivery systems exploit and/or promote cellular entry via caveolae. A vast majority of studies employ pharmacological tools, co-localization experiments and very few make use of molecular tools. We provide clarification on how results of such studies should be interpreted and make suggestions for future studies.
Keyword Caveolae
Caveolin-1
Cavin-1
Drug delivery
Endocytosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
Centre for Microscopy and Microanalysis Publications
 
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