Prefrontal cortex involvement in selective letter generation: A functional magnetic resonance imaging study

DE Zubicaray, G. I., Williams, S. C. R., Wilson, S. J., Rose, S. E., Brammer, M. J., Bullmore, E. T., Simmons, A., Chalk, J. B., Brown, A. P., Ashton, R. and Doddrell, D. M. (1998) Prefrontal cortex involvement in selective letter generation: A functional magnetic resonance imaging study. Cortex, 34 3: 389-401. doi:10.1016/S0010-9452(08)70762-7


Author DE Zubicaray, G. I.
Williams, S. C. R.
Wilson, S. J.
Rose, S. E.
Brammer, M. J.
Bullmore, E. T.
Simmons, A.
Chalk, J. B.
Brown, A. P.
Ashton, R.
Doddrell, D. M.
Title Prefrontal cortex involvement in selective letter generation: A functional magnetic resonance imaging study
Journal name Cortex   Check publisher's open access policy
ISSN 0010-9452
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.1016/S0010-9452(08)70762-7
Volume 34
Issue 3
Start page 389
End page 401
Total pages 13
Language eng
Abstract Cerebral responses to alternating periods of a control task and a selective letter generation paradigm were investigated with functional Magnetic Resonance Imaging (fMRI). Subjects selectively generated letters from four designated sets of six letters from the English language alphabet, with the instruction that they were not to produce letters in alphabetical order either forward or backward, repeat or alternate letters. Performance during this condition was compared with that of a control condition in which subjects recited the same letters in alphabetical order. Analyses revealed significant and extensive foci of activation in a number of cerebral regions including mid-dorsolateral frontal cortex, inferior frontal gyrus, precuneus, supramarginal gyrus, and cerebellum during the selective letter generation condition. These findings are discussed with respect to recent positron emission tomography (PET) and fMRI studies of verbal working memory and encoding/retrieval in episodic memory.
Keyword Behavioral Sciences
Neurosciences
Functional Magnetic Resonance Imaging
Random Generation
Working Memory
Prefrontal Cortex
Working-memory
Sustained Attention
Episodic Memory
Frontal Lesions
Activation
Retrieval
Network
Fmri
Pet
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Mon, 13 Aug 2007, 20:31:51 EST