Genetics of Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): current knowledge and future directions

Blum, Stefan and McCombe, Pamela A. (2014) Genetics of Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): current knowledge and future directions. Journal of the Peripheral Nervous System, 19 2: 88-103. doi:10.1111/jns5.12074


Author Blum, Stefan
McCombe, Pamela A.
Title Genetics of Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): current knowledge and future directions
Journal name Journal of the Peripheral Nervous System   Check publisher's open access policy
ISSN 1085-9489
1529-8027
Publication date 2014-06
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/jns5.12074
Open Access Status
Volume 19
Issue 2
Start page 88
End page 103
Total pages 16
Place of publication Hoboken, United States
Publisher Wiley-Blackwell Publishing
Collection year 2015
Language eng
Formatted abstract
Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are thought to be autoimmune diseases. There have been many attempts to find a human leukocyte antigen (HLA) association with GBS and CIDP with little success. There have been studies of other plausible genes in GBS and CIDP and the role of these genes in GBS and CIDP and the data from these genetic studies is reviewed. Some of the genes that have been studied are immune related and some others have nervous system effects. The studies are limited by small numbers. Some of the genes show association with disease severity rather than disease susceptibility. The need for more detailed molecular studies of the role of HLA molecules and the need for modern genetic approaches to GBS and CIDP are explained.
Keyword Cd1
Chronic inflammatory demyelinating polyradiculoneuropathy
Disease associations
Genetics
Guillain-Barre syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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