Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles

Anitha, A., Divya Rani, V. V., Krishna, R., Sreeja, V., Selvamurugan, N., Nair, S. V., Tamura, H. and Jayakumar, R. (2009) Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles. Carbohydrate Polymers, 78 4: 672-677. doi:10.1016/j.carbpol.2009.05.028


Author Anitha, A.
Divya Rani, V. V.
Krishna, R.
Sreeja, V.
Selvamurugan, N.
Nair, S. V.
Tamura, H.
Jayakumar, R.
Title Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O-carboxymethyl chitosan nanoparticles
Journal name Carbohydrate Polymers   Check publisher's open access policy
ISSN 0144-8617
1879-1344
Publication date 2009-11-17
Sub-type Article (original research)
DOI 10.1016/j.carbpol.2009.05.028
Open Access Status
Volume 78
Issue 4
Start page 672
End page 677
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Chitosan (CS) is a naturally occurring biopolymer. It has important biological properties such as biocompatibility, antifungal and antibacterial activity, wound healing ability, anticancerous property, anticholesteremic properties, and immunoenhancing effect. Recently, CS nanoparticles have been used for biomedical applications. However, due to the limited solubility of CS in water its water-soluble derivatives are preferred for the above said applications. In this work, the nanoparticles of CS and its water-soluble derivatives such as O-carboxymethyl chitosan (O-CMC) and N,O-carboxymethyl chitosan (N,O-CMC) was synthesized and characterized. In addition, cytotoxicity and antibacterial activity of the prepared nanoparticles was also evaluated for biomedical applications.
Keyword Chitosan nanoparticles
Carboxymethyl derivatives
Cytotoxicity
Antibacterial
Biomaterials
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 22 Jan 2015, 13:49:38 EST by Anitha Sudheesh Kumar on behalf of School of Chemistry & Molecular Biosciences