The global burden of rheumatoid arthritis: Estimates from the Global Burden of Disease 2010 study

Cross, Marita, Smith, Emma, Hoy, Damian, Carmona, Loreto, Wolfe, Frederick, Vos, Theo, Williams, Benjamin, Gabriel, Sherine, Lassere, Marissa, Johns, Nicole, Buchbinder, Rachelle, Woolf, Anthony and March, Lyn (2014) The global burden of rheumatoid arthritis: Estimates from the Global Burden of Disease 2010 study. Annals of the Rheumatic Diseases, 73 7: 1316-1322. doi:10.1136/annrheumdis-2013-204627

Author Cross, Marita
Smith, Emma
Hoy, Damian
Carmona, Loreto
Wolfe, Frederick
Vos, Theo
Williams, Benjamin
Gabriel, Sherine
Lassere, Marissa
Johns, Nicole
Buchbinder, Rachelle
Woolf, Anthony
March, Lyn
Title The global burden of rheumatoid arthritis: Estimates from the Global Burden of Disease 2010 study
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1136/annrheumdis-2013-204627
Open Access Status
Volume 73
Issue 7
Start page 1316
End page 1322
Total pages 7
Place of publication London, United Kingdom
Publisher BMJ Publishing Group
Collection year 2015
Language eng
Formatted abstract
Objectives To estimate the global burden of rheumatoid arthritis (RA), as part of the Global Burden of Disease 2010 study of 291 conditions and how the burden of RA compares with other conditions.

Methods The optimum case definition of RA for the study was the American College of Rheumatology 1987 criteria. A series of systematic reviews were conducted to gather age-sex-specific epidemiological data for RA prevalence, incidence and mortality. Cause-specific mortality data were also included. Data were entered into DisMod-MR, a tool to pool available data, making use of study-level covariates to adjust for country, region and super-region random effects to estimate prevalence for every country and over time. The epidemiological data, in addition to disability weights, were used to calculate years of life lived with disability (YLDs). YLDs were added to the years of life lost due to premature mortality to estimate the overall burden (disability-adjusted life years (DALYs)) for RA for the years 1990, 2005 and 2010.

Results The global prevalence of RA was 0.24% (95% CI 0.23% to 0.25%), with no discernible change from 1990 to 2010. DALYs increased from 3.3 million (M) (95% CI 2.6 M to 4.1 M) in 1990 to 4.8 M (95% CI 3.7 M to 6.1 M) in 2010. This increase was due to a growth in population and increase in aging. Globally, of the 291 conditions studied, RA was ranked as the 42nd highest contributor to global disability, just below malaria and just above iodine deficiency (measured in YLDs).

Conclusions RA continues to cause modest global disability, with severe consequences in the individuals affected.
Keyword Global burden
Rheumatoid Arthritis (ra)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
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Created: Wed, 21 Jan 2015, 11:14:17 EST by Nyree Divitini on behalf of School of Public Health