Healthy obese versus unhealthy lean: the obesity paradox

Lavie, Carl J., De Schutter, Alban and Milani, Richard V. (2015) Healthy obese versus unhealthy lean: the obesity paradox. Nature Reviews Endocrinology, 11 1: 55-62. doi:10.1038/nrendo.2014.165

Author Lavie, Carl J.
De Schutter, Alban
Milani, Richard V.
Title Healthy obese versus unhealthy lean: the obesity paradox
Journal name Nature Reviews Endocrinology   Check publisher's open access policy
ISSN 1759-5029
Publication date 2015-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrendo.2014.165
Open Access Status
Volume 11
Issue 1
Start page 55
End page 62
Total pages 8
Place of publication London United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Overweight and obesity have reached epidemic proportions in the USA and most of the rest of the world. Particularly concerning is the very high prevalence of class III obesity (BMI ≥40 kg/m2), which has reached ~3% in the USA. In the past few years, controversy has surrounded the idea that some individuals with obesity can be considered healthy with regards to their metabolic and cardiorespiratory fitness, which has been termed the 'obesity paradox'. These controversies are reviewed in detail here, including discussion of the very favourable prognosis in patients with obesity who have no notable metabolic abnormalities and who have preserved fitness. The article also discusses the suggestion that greater emphasis should be placed on improving fitness rather than weight loss per se in the primary and secondary prevention of cardiovascular diseases, at least in patients with overweight and class I obesity (BMI 30–35 kg/m2).
Keyword Coronary heart disease
All cause mortality
Body mass index
Life style intervention
Cardiorespiratory fitness
Cardiovascular disease
Weight loss
Metabolically healthy
Risk factors
Prognostic importance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 30 Sep 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
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