CD4+/CD8+ double positive T cells: more than just a developmental stage?

Overgaard, Nana H., Jung, Ji-Won, Steptoe, Raymond J. and Wells, James W. (2015) CD4+/CD8+ double positive T cells: more than just a developmental stage?. Journal of Leukocyte Biology, 97 1: 31-38. doi:10.1189/jlb.1RU0814-382


Author Overgaard, Nana H.
Jung, Ji-Won
Steptoe, Raymond J.
Wells, James W.
Title CD4+/CD8+ double positive T cells: more than just a developmental stage?
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
1938-3673
Publication date 2015-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1189/jlb.1RU0814-382
Open Access Status
Volume 97
Issue 1
Start page 31
End page 38
Total pages 8
Place of publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Collection year 2016
Language eng
Formatted abstract
CD4+/CD8+ DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4+ lineage or the CD8+ lineage is generally considered to be fixed. Nevertheless, mature CD4+/CD8+ DP T cells have been described in the blood and peripheral lymphoid tissues of numerous species, as well as in numerous disease settings, including cancer. The expression of CD4 and CD8 is regulated by a very strict transcriptional program involving the transcription factors Runx3 and ThPOK. Initially thought to be mutually exclusive within CD4+ and CD8+ T cells, CD4+/CD8+ T cell populations, outside of the thymus, have recently been described to express concurrently ThPOK and Runx3. Considerable heterogeneity exists within the CD4+/CD8+ DP T cell pool, and the function of CD4+/CD8+ T cell populations remains controversial, with conflicting reports describing cytotoxic or suppressive roles for these cells. In this review, we describe how transcriptional regulation, lineage of origin, heterogeneity of CD4 and CD8 expression, age, species, and specific disease settings influence the functionality of this rarely studied T cell population.
Keyword Immune regulation
Cytotoxic potential
T cell plasticity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 17 Jan 2015, 08:58:19 EST by Dr James Wells on behalf of UQ Diamantina Institute