Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile?

Wells, James W. (2015). Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile?. In H. Peter Soyer, Tarl W. Prow and Gregor B. E. Jemec (Ed.), Actinic keratosis (pp. 36-41) Basel, Switzerland: Karger AG. doi:10.1159/000366533

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Author Wells, James W.
Title of chapter Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile?
Title of book Actinic keratosis
Place of Publication Basel, Switzerland
Publisher Karger AG
Publication Year 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1159/000366533
Open Access Status Not Open Access
Series Current Problems in Dermatology
ISBN 9783318027624
ISSN 1662-2944
Editor H. Peter Soyer
Tarl W. Prow
Gregor B. E. Jemec
Volume number 46
Chapter number 6
Start page 36
End page 41
Total pages 6
Total chapters 21
Collection year 2016
Language eng
Formatted Abstract/Summary
The link between actinic keratosis (AK), squamous cell carcinoma (SCC), and a fully functional immune system has been frequently observed but is poorly understood. Elderly and immunosuppressed individuals and those with weakened immune systems caused by disease are all at increased risk of developing AK and/or SCC. This risk is particularly enhanced at sites that receive high levels of ultraviolet exposure from the sun, which is thought to be a driver of DNA mutations in the skin. The immune system appears to play a key role in preventing these mutations from progressing to malignant disease. AK is often considered to be a pre-cancerous lesion that may develop into SCC. However, the vast majority of AKs, in contrast to SCCs, regress naturally or in response to immune-modifying medications. The cellular mechanisms involved in this immune-based process remain elusive and raise the following question: does the immune make-up or immune functionality within AK differ fundamentally from that within SCC? This chapter will outline the skin as a site of considerable immunological activity, highlight the consequences of dysregulated immune activity in the skin, and discuss what little we know of immune infiltrates and their associated functions within AK and SCC
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
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Created: Sat, 17 Jan 2015, 08:50:33 EST by Dr James Wells on behalf of UQ Diamantina Institute