Fossilized venom: the unusually conserved venom profiles of heloderma species (beaded lizards and gila monsters).

Koludarov, Ivan, Jackson, Timothy N. W., Sunagar, Kartik, Nouwens, Amanda, Hendrikx, Iwan and Fry, Bryan G. (2014) Fossilized venom: the unusually conserved venom profiles of heloderma species (beaded lizards and gila monsters).. Toxins, 6 12: 3582-3595. doi:10.3390/toxins6123582


Author Koludarov, Ivan
Jackson, Timothy N. W.
Sunagar, Kartik
Nouwens, Amanda
Hendrikx, Iwan
Fry, Bryan G.
Title Fossilized venom: the unusually conserved venom profiles of heloderma species (beaded lizards and gila monsters).
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2014-12-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/toxins6123582
Open Access Status DOI
Volume 6
Issue 12
Start page 3582
End page 3595
Total pages 14
Place of publication Basel, Switzerland
Publisher MDPI
Collection year 2015
Language eng
Formatted abstract
Research into snake venoms has revealed extensive variation at all taxonomic levels. Lizard venoms, however, have received scant research attention in general, and no studies of intraclade variation in lizard venom composition have been attempted to date. Despite their iconic status and proven usefulness in drug design and discovery, highly venomous helodermatid lizards (gila monsters and beaded lizards) have remained neglected by toxinological research. Proteomic comparisons of venoms of three helodermatid lizards in this study has unravelled an unusual similarity in venom-composition, despite the long evolutionary time (~30 million years) separating H. suspectum from the other two species included in this study (H. exasperatum and H. horridum). Moreover, several genes encoding the major helodermatid toxins appeared to be extremely well-conserved under the influence of negative selection (but with these results regarded as preliminary due to the scarcity of available sequences). While the feeding ecologies of all species of helodermatid lizard are broadly similar, there are significant morphological differences between species, which impact upon relative niche occupation
Keyword Adaptive Evolution
Venom
adaptive evolution; venom; toxin; Heloderma; beaded lizard; gila monster
Toxin
Heloderma
Beaded lizard
Gila monster
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biological Sciences Publications
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 16 Jan 2015, 20:59:22 EST by Mrs Louise Nimwegen on behalf of School of Biological Sciences