Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery.

Christie, Michelle P., Toth, Istvan and Simerska, Pavla (2014) Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery.. Future Medicinal Chemistry, 6 18: 2113-2129. doi:10.4155/fmc.14.130


Author Christie, Michelle P.
Toth, Istvan
Simerska, Pavla
Title Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery.
Journal name Future Medicinal Chemistry   Check publisher's open access policy
ISSN 1756-8919
Publication date 2014-12
Year available 2014
Sub-type Article (original research)
DOI 10.4155/fmc.14.130
Open Access Status
Volume 6
Issue 18
Start page 2113
End page 2129
Total pages 17
Place of publication London, United Kingdom
Publisher Future Science
Collection year 2015
Language eng
Formatted abstract
Lectin–glycan interactions play a role in biological processes, host–pathogen interactions and in disease. A more detailed understanding of these interactions is not only useful for the elucidation of their biological function but can also be applied in immunology, drug development and delivery and diagnostics. We review some commonly used biophysical techniques for studying lectin–glycan interactions; namely: frontal affinity chromatography, glycan/lectin microarray, surface plasmon resonance, electrochemical impedance spectroscopy, isothermal titration calorimetry, fluorescent assays, enzyme linked lectin sorbent assay and saturation transfer difference nuclear magnetic resonance spectroscopy. Each method is evaluated on efficiency, cost and throughput. We also consider the advantages and limitations of each technique and provide examples of their application in biology, drug discovery and delivery, immunology, glycoprofiling and biosensing.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
 
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Created: Fri, 16 Jan 2015, 10:46:43 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences