Microscopic diffusion properties of fixed breast tissue: Preliminary findings

Norddin, Narina, Power, Carl, Watson, Geoffrey, Cowin, Gary, Kurniawan, Nyoman D., Gluch, Laurence and Bourne, Roger M. (2014) Microscopic diffusion properties of fixed breast tissue: Preliminary findings. Magnetic Resonance in Medicine, 74 6: 1733-1739. doi:10.1002/mrm.25555

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ349150_OA.pdf Full text (open access) application/pdf 202.24KB 12

Author Norddin, Narina
Power, Carl
Watson, Geoffrey
Cowin, Gary
Kurniawan, Nyoman D.
Gluch, Laurence
Bourne, Roger M.
Title Microscopic diffusion properties of fixed breast tissue: Preliminary findings
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1002/mrm.25555
Open Access Status File (Author Post-print)
Volume 74
Issue 6
Start page 1733
End page 1739
Total pages 7
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons
Collection year 2015
Language eng
Formatted abstract
To investigate the microscopic diffusion properties of formalin-fixed breast tissue.

Diffusion microimaging was performed at 16.4T with 40-μm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples.


Diffusion-weighted images and mean diffusivity maps demonstrated distinct diffusivity differences between breast tissue components. Mean diffusivity (MD) in normal tissue was 0.59 ± 0.24 μm2/ms for gland lobule (voxels containing epithelium and intralobular stroma) and 1.23 ± 0.34 μm2/ms for interlobular fibrous stroma. In the cancer samples, MD = 0.45 ± 0.23 μm2/ms for invasive ductal carcinoma (voxels contain epithelium and intralobular stroma) and 0.61 ± 0.35 μm2/ms for ductal carcinoma in situ. There were significant MD differences between all tissue components (P < 0.005), except between gland lobule and ductal carcinoma in situ (P = 0.71). The low diffusivity of epithelium-rich cancer tissue and of normal epithelium relative to its supporting fibrous stroma was similar to that reported for prostate tissue and the esophageal wall.

Diffusion microimaging demonstrates distinct diffusivity differences between breast tissue glandular structures. Low diffusivity may be a distinctive feature of mammalian epithelia.
Keyword Breast
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 15 Jan 2015, 14:04:55 EST by Shona Osborne on behalf of Centre for Advanced Imaging