Tropoelastin incorporation into a dermal regeneration template promotes wound angiogenesis

Wang, Yiwei, Mithieux, Suzanne M., Kong, Yvonne, Wang, Xue-Qing, Chong, Cassandra, Fathi, Ali, Dehghani, Fariba, Panas, Eleni, Kemnitzer, John, Daniels, Robert, Kimble, Roy M., Maitz, Peter K., Li, Zhe and Weiss, Anthony S. (2014) Tropoelastin incorporation into a dermal regeneration template promotes wound angiogenesis. Advanced Healthcare Materials, 4 4: 577-584. doi:10.1002/adhm.201400571

Author Wang, Yiwei
Mithieux, Suzanne M.
Kong, Yvonne
Wang, Xue-Qing
Chong, Cassandra
Fathi, Ali
Dehghani, Fariba
Panas, Eleni
Kemnitzer, John
Daniels, Robert
Kimble, Roy M.
Maitz, Peter K.
Li, Zhe
Weiss, Anthony S.
Title Tropoelastin incorporation into a dermal regeneration template promotes wound angiogenesis
Journal name Advanced Healthcare Materials   Check publisher's open access policy
ISSN 2192-2659
Publication date 2014-12-02
Year available 2014
Sub-type Article (original research)
DOI 10.1002/adhm.201400571
Open Access Status
Volume 4
Issue 4
Start page 577
End page 584
Total pages 8
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Collection year 2015
Language eng
Abstract Severe burn injury results in substantial skin loss and cannot be treated by autografts. The Integra Dermal Regeneration Template (IDRT) is the lead- ing synthetic skin substitute because it allows for wound bed regeneration and wound healing. However, all substitutes suffer from slow blood vessel ingrowth and would benefi t considerably from enhanced vascularization to nurture tissue repair. It is shown here that by incorporating the human elastic protein tropoelastin into a dermal regeneration template (TDRT) we can pro- mote angiogenesis in wound healing. In small and large animal models com- prising mice and pigs, the hybrid TDRT biomaterial and IDRT show similar contraction to autografts and decrease wound contraction compared to open wounds. In mice, TDRT accelerates early stage angiogenesis by 2 weeks, as evidenced by increased angiogenesis fl uorescent radiant effi ciency in live ani- mal imaging and the expression of endothelial cell adhesion marker CD146. In the pig, a full thickness wound repair model confi rms increased numbers of blood vessels in the regenerating areas of the dermis closest to the hypo- dermis and immediately below the epidermis at 2 weeks post-surgery. It is concluded that including tropoelastin in a dermal regeneration template has the potential to promote wound repair through enhanced vascularization.
Keyword Dermal substitute
Wound healing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 2 DEC 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
School of Medicine Publications
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Created: Thu, 15 Jan 2015, 12:11:29 EST by Matthew Lamb on behalf of School of Medicine