Age differences in brain activity related to unsuccessful declarative memory retrieval

Grady, Cheryl L., St-Laurent, Marie and Burianova, Hana (2015) Age differences in brain activity related to unsuccessful declarative memory retrieval. Brain Research, 1612 30-47. doi:10.1016/j.brainres.2014.12.036

Author Grady, Cheryl L.
St-Laurent, Marie
Burianova, Hana
Title Age differences in brain activity related to unsuccessful declarative memory retrieval
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 2015-07
Sub-type Article (original research)
DOI 10.1016/j.brainres.2014.12.036
Open Access Status
Volume 1612
Start page 30
End page 47
Total pages 18
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Although memory recall is known to be reduced with normal aging, little is known about the patterns of brain activity that accompany these recall failures. By assessing faulty memory, we can identify the brain regions engaged during retrieval attempts in the absence of successful memory and determine the impact of aging on this functional activity. We used functional magnetic resonance imaging to examine age differences in brain activity associated with memory failure in three memory retrieval tasks: autobiographical (AM), episodic (EM) and semantic (SM). Compared to successful memory retrieval, both age groups showed more activity when they failed to recall a memory in regions consistent with the salience network (SLN), a brain network also associated with non-memory errors. Both groups also showed strong functional coupling among SLN regions during incorrect trials and in intrinsic patterns of functional connectivity. In comparison to young adults, older adults demonstrated (1) less activity within the SLN during unsuccessful AM trials; (2) weaker intrinsic functional connectivity between SLN nodes and dorsolateral prefrontal cortex; and (3) less differentiation of SLN functional connectivity during incorrect trials across memory conditions. These results suggest that the SLN is engaged during recall failures, as it is for non-memory errors, which may be because errors in general have particular salience for adapting behavior. In older adults, the dedifferentiation of functional connectivity within the SLN across memory conditions and the reduction of functional coupling between it and prefrontal cortex may indicate poorer inter-network communication and less flexible use of cognitive control processes, either while retrieval is attempted or when monitoring takes place after retrieval has failed.
Keyword fMRI
Episodic memory
Salience network
Frontal lobe
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 14 Jan 2015, 16:13:35 EST by Shona Osborne on behalf of Centre for Advanced Imaging