Polymeric siRNA delivery vectors: knocking down cancers with polymeric‐based gene delivery systems

Ardana, Aditya, Whittaker, Andrew, McMillan, Nigel A. J. and Thurecht, Kristofer J. (2014) Polymeric siRNA delivery vectors: knocking down cancers with polymeric‐based gene delivery systems. Journal of Chemical Technology and Biotechnology, 90 7: 1196-1208. doi:10.1002/jctb.4508


Author Ardana, Aditya
Whittaker, Andrew
McMillan, Nigel A. J.
Thurecht, Kristofer J.
Title Polymeric siRNA delivery vectors: knocking down cancers with polymeric‐based gene delivery systems
Journal name Journal of Chemical Technology and Biotechnology   Check publisher's open access policy
ISSN 0268-2575
1097-4660
Publication date 2014-09-09
Year available 2014
Sub-type Article (original research)
DOI 10.1002/jctb.4508
Open Access Status
Volume 90
Issue 7
Start page 1196
End page 1208
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley and Sons
Collection year 2015
Language eng
Formatted abstract
One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering
RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and
gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and
efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other
diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy.
Keyword siRNA
Polymers
Macromolecules
Gene therapy
Dendrimers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Wed, 14 Jan 2015, 13:55:27 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology