A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies

Chan, Alexandre, Cameron, Michael C., Garden, Benjamin, Boers-Doets, Christine B., Schindler, Katja, Epstein, Joel B., Choi, Jennifer, Beamer,Laure, Roeland, Eric, Russi, Elvio G., Bensadoun, René-Jean, Teo, Yi Ling, Chan, Raymond J., Shih, Vivianne, Bryce, Jane, Raber-Durlacher, Judith, Gerber, Peter Arne, Freytes, César O., Rapoport, Bernardo, LeBoeuf, Nicole, Sibaud, Vincent and Lacouture, Mario E. (2015) A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies. Supportive Care in Cancer, 23 8: 2231-2244. doi:10.1007/s00520-014-2564-x

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Author Chan, Alexandre
Cameron, Michael C.
Garden, Benjamin
Boers-Doets, Christine B.
Schindler, Katja
Epstein, Joel B.
Choi, Jennifer
Roeland, Eric
Russi, Elvio G.
Bensadoun, René-Jean
Teo, Yi Ling
Chan, Raymond J.
Shih, Vivianne
Bryce, Jane
Raber-Durlacher, Judith
Gerber, Peter Arne
Freytes, César O.
Rapoport, Bernardo
LeBoeuf, Nicole
Sibaud, Vincent
Lacouture, Mario E.
Title A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies
Journal name Supportive Care in Cancer   Check publisher's open access policy
ISSN 0941-4355
Publication date 2015-01-07
Year available 2015
Sub-type Article (original research)
DOI 10.1007/s00520-014-2564-x
Open Access Status
Volume 23
Issue 8
Start page 2231
End page 2244
Total pages 14
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2016
Language eng
Formatted abstract
Dermatologic adverse events (dAEs) in cancer treatment are frequent with the use of targeted therapies. These dAEs have been shown to have significant impact on health-related quality of life (HRQoL). While standardized assessment tools have been developed for physicians to assess severity of dAEs, there is a discord between objective and subjective measures. The identification of patient-reported outcome (PRO) instruments useful in the context of targeted cancer therapies is therefore important in both the clinical and research settings for the overall evaluation of dAEs and their impact on HRQoL.

A comprehensive, systematic literature search of published articles was conducted by two independent reviewers in order to identify PRO instruments previously utilized in patient populations with dAEs from targeted cancer therapies. The identified PRO instruments were studied to determine which HRQoL issues relevant to dAEs were addressed, as well as the process of development and validation of these instruments.

Thirteen articles identifying six PRO instruments met the inclusion criteria. Four instruments were general dermatology (Skindex-16©, Skindex-29©, Dermatology Life Quality Index (DLQI), and DIELH-24) and two were symptom-specific (functional assessment of cancer therapy-epidermal growth factor receptor inhibitor-18 (FACT-EGFRI-18) and hand-foot syndrome 14 (HFS-14)).

While there are several PRO instruments that have been tested in the context of targeted cancer therapy, additional work is needed to develop new instruments and to further validate the instruments identified in this study in patients receiving targeted therapies.
Keyword Targeted cancer therapy
Dermatologic adverse events
Patient reported outcomes
Health related quality of life
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Nursing, Midwifery and Social Work Publications
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Created: Wed, 14 Jan 2015, 09:09:47 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work