Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules

Wibowo, David, Zhao, Chun-Xia, Peters, Brenton C. and Middelberg, Anton P. J. (2014) Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules. Journal of Agricultural and Food Chemistry, 62 52: 12504-12511. doi:10.1021/jf504455x


Author Wibowo, David
Zhao, Chun-Xia
Peters, Brenton C.
Middelberg, Anton P. J.
Title Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules
Formatted title
Sustained release of fipronil insecticide in Vitro and in Vivo from biocompatible silica nanocapsules
Journal name Journal of Agricultural and Food Chemistry   Check publisher's open access policy
ISSN 1520-5118
0021-8561
Publication date 2014-12-31
Year available 2014
Sub-type Article (original research)
DOI 10.1021/jf504455x
Volume 62
Issue 52
Start page 12504
End page 12511
Total pages 8
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2015
Language eng
Formatted abstract
A pesticide delivery system made of biocompatible components and having sustained release properties is highly desirable for agricultural applications. In this study, we report a new biocompatible oil-core silica-shell nanocapsule for sustained release of fipronil insecticide. Silica nanocapsules were prepared by a recently reported emulsion and biomimetic dual-templating approach under benign conditions and without using any toxic chemicals. The loading of fipronil was achieved by direct dissolution in the oil core prior to biomimetic growth of a layer of silica shell surrounding the core, with encapsulation efficiency as high as 73%. Sustained release of fipronil in vitro was tunable through control of the silica-shell thickness (i.e., 8–44 nm). In vivo laboratory tests showed that the insecticidal effect of the fipronil-encapsulated silica nanocapsules against economically important subterranean termites could be controlled by tuning the shell thickness. These studies demonstrated the effectiveness and tunability of an environmentally friendly sustained release system for insecticide, which has great potential for broader agricultural applications with minimal environmental risks.
Keyword Silica
Nanocapsules
Sustained release
Insecticides
Fipronil
Subterranean termites
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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