Associations between meal size, gastric emptying and post-prandial plasma glucose, insulin and lactate concentrations in meal-fed cats

Coradini, M., Rand, J. S., Filippich, L. J., Morton, J. M. and O'Leary, C. A. (2014) Associations between meal size, gastric emptying and post-prandial plasma glucose, insulin and lactate concentrations in meal-fed cats. Journal of Animal Physiology and Animal Nutrition, 99 4: 757-766. doi:10.1111/jpn.12280


Author Coradini, M.
Rand, J. S.
Filippich, L. J.
Morton, J. M.
O'Leary, C. A.
Title Associations between meal size, gastric emptying and post-prandial plasma glucose, insulin and lactate concentrations in meal-fed cats
Journal name Journal of Animal Physiology and Animal Nutrition   Check publisher's open access policy
ISSN 1439-0396
0931-2439
Publication date 2014-12-26
Year available 2014
Sub-type Article (original research)
DOI 10.1111/jpn.12280
Open Access Status
Volume 99
Issue 4
Start page 757
End page 766
Total pages 10
Place of publication Berlin, Germany
Publisher Wiley-Blackwell
Collection year 2015
Language eng
Abstract Plasma glucose and insulin concentrations are increased for 12–24 h in healthy cats following moderate- to high-carbohydrate meals. This study investigated associations between gastric emptying time and post-prandial plasma glucose, insulin and lactate concentrations in cats fed an extruded dry, high-carbohydrate, moderate-fat, low-protein diet (51, 28, 21% metabolizable energy, respectively) once daily by varying meal volume. Eleven healthy, non-obese, neutered adult cats were enrolled in a prospective study and fed to maintain body weight. Ultrasound examinations were performed for up to 26 h, and blood collections over 24 h after eating meals containing approximately 100% and 50% of the cats’ daily caloric intake (209 and 105 kJ/kg BW, respectively). Gastric emptying time was increased after a meal of 209 kJ/kg BW compared with 105 kJ/kg BW (median gastric emptying times 24 and 14 h, respectively; p = 0.03). Time for glucose to return to fasting was longer after the 209 kJ/kg BW meal (median 20 h; 25th and 75th percentiles 15 and 23 h, respectively) than the 105 kJ/kg BW meal (13, 12 and 14 h; p < 0.01); however, peak glucose was not higher after the 209 kJ/kg BW meal compared with the 105 kJ/kg BW meal ((mean ± SD) 6.6 ± 0.6 and 7.8 ± 1.2 mmol/l, respectively, p = 0.07). Times for insulin to return to fasting were not significantly longer after the 209 kJ/kg BW meal than the 105 kJ/kg BW meal (p = 0.29). d- and l-lactate concentrations were not associated with gastric emptying time or post-prandial blood glucose and insulin. Based on results obtained, prolonged gastric emptying contributes to prolonged post-prandial hyperglycemia in cats meal fed a high-carbohydrate, low-protein, dry diet and fasting times for cats’ meal-fed diets of similar composition should be 14–26 h, depending on meal size.
Keyword Antral area
Antral volume
Gastric emptying
Glycemia
Insulin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 26 December 2014. Early View (Online Version of Record published before inclusion in an issue)

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Veterinary Science Publications
 
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