Serotonergic modulation of spinal motor control

Perrier, Jean-Francois and Cotel, Florence (2015) Serotonergic modulation of spinal motor control. Current Opinion in Neurobiology, 33 1-7. doi:10.1016/j.conb.2014.12.008


Author Perrier, Jean-Francois
Cotel, Florence
Title Serotonergic modulation of spinal motor control
Journal name Current Opinion in Neurobiology   Check publisher's open access policy
ISSN 1873-6882
0959-4388
Publication date 2015-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.conb.2014.12.008
Open Access Status
Volume 33
Start page 1
End page 7
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Abstract Serotonin (5-HT) is a monoamine that powerfully modulates spinal motor control by acting on intrasynaptic and extrasynaptic receptors. Here we review the diversity of 5-HT actions on locomotor and motoneuronal activities. Two approaches have been used on in vitro spinal cord preparations: either applying 5-HT in the extracellular medium or inducing its synaptic release. They produced strikingly different results suggesting that the net effect of 5-HT depends on the identity of the activated receptors and their location. Recent findings suggest that moderate release of 5-HT facilitates locomotion and promotes the excitability of motoneurons, while stronger release inhibits rhythmic activity and motoneuron firing. This latter effect is responsible for central fatigue and secures rotation of motor units.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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