Can intraoperative intraocular pressure during primary trabeculectomy predict early postoperative pressure?

Rong, Shi Song, Meng, Hai Lin, Fan, Su Jie, Wang, Ning Li, Liang, Yuan Bo, Huang, Yao, Wang, Rui, He, Yanqing, Chang, Xinqi, Cui, Hong Yu, Zhang, Zhi Hong, Li, Si Zhen, Liu, Luo Ru and Thomas, Ravi (2014) Can intraoperative intraocular pressure during primary trabeculectomy predict early postoperative pressure?. Journal of Glaucoma, 23 9: 653-657. doi:10.1097/IJG.0b013e318285ff44

Author Rong, Shi Song
Meng, Hai Lin
Fan, Su Jie
Wang, Ning Li
Liang, Yuan Bo
Huang, Yao
Wang, Rui
He, Yanqing
Chang, Xinqi
Cui, Hong Yu
Zhang, Zhi Hong
Li, Si Zhen
Liu, Luo Ru
Thomas, Ravi
Title Can intraoperative intraocular pressure during primary trabeculectomy predict early postoperative pressure?
Journal name Journal of Glaucoma   Check publisher's open access policy
ISSN 1536-481X
Publication date 2014-12
Year available 2014
Sub-type Article (original research)
DOI 10.1097/IJG.0b013e318285ff44
Open Access Status
Volume 23
Issue 9
Start page 653
End page 657
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams and Wilkins
Collection year 2015
Language eng
Formatted abstract
Purpose: To study the association of intraoperative intraocular pressure (IOP) at the conclusion of primary trabeculectomy with postoperative IOP on days 1, 7, and 30 and report the ability of intraoperative IOP to predict early postoperative IOP.

Patients and Methods: Prospective, observational, case series. Ninety-seven consecutive patients with primary open-angle or angle-closure glaucoma underwent primary trabeculectomy. The IOP was measured 3 minutes after the closure of scleral flap with a formed anterior chamber. Clinical details and complications were recorded over a 30-day follow-up. The patients were grouped as A (intraoperative IOP<=10.0 mm Hg), B (>10, <=15.0 mm Hg), and C (>15 mm Hg).

Results: Mean age was 60.8±9.9 years. Forty (41.3%) patients were males. Eighty-two (84.5%) had primary angle-closure glaucoma. Mitomycin-c (MMC) was used in 75 (77.3%) eyes. Mean IOP in group C was significantly higher than group A at all visits (P=0.005, 0.002, and 0.05). Postoperative IOP was associated with intraoperative IOP, age, duration, and dose of MMC in univariable regressions. On multivariable analysis, the intraoperative IOP was associated with postoperative IOP’s on day 1 (regression coefficient b=0.24, P=0.039, R2=0.24) and day 7 (b=0.47, P<0.001, R2=0.42), but not on day 30 (b=0.22, P=0.065, R2=0.12). IOP on day 7 was predicted by -8.6+0.47×(intraoperative IOP)+0.27×age-11.7×(dose of MMC in mg/mL). Prediction for day 30=9.8+0.27×(intraoperative IOP).

Conclusions: In patients undergoing uncomplicated primary trabeculectomy, intraoperative IOP is associated with and may predict early postoperative IOP. Adjusting the IOP during the operation may optimize postoperative IOP.
Keyword Glaucoma
Intraocular pressure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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