Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

Master, Jordanna S., Zimanyi, Monika A., Yin, Kom V., Moritz, Karen M., Gallo, Linda A., Tran, Melanie, Wlodek, Mary E. and Black, Mary J. (2014) Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats. Clinical and Experimental Pharmacology and Physiology, 41 11: 884-890. doi:10.1111/1440-1681.12303


Author Master, Jordanna S.
Zimanyi, Monika A.
Yin, Kom V.
Moritz, Karen M.
Gallo, Linda A.
Tran, Melanie
Wlodek, Mary E.
Black, Mary J.
Title Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
0305-1870
Publication date 2014-11
Year available 2014
Sub-type Article (original research)
DOI 10.1111/1440-1681.12303
Open Access Status
Volume 41
Issue 11
Start page 884
End page 890
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2015
Language eng
Formatted abstract
Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subsequent generations. The aim of the present study was to examine the effect of intrauterine growth restriction in rats, induced by uteroplacental insufficiency, on cardiac structure, number, size, nuclearity, and adult blood pressure in first (F1) and second (F2) generation male offspring. Uteroplacental insufficiency or sham surgery was induced in F0 Wistar-Kyoto pregnant rats in late gestation giving rise to F1 restricted and control offspring, respectively. F1 control and restricted females were mated with normal males, resulting in F2 control and restricted offspring, respectively. F1 restricted male offspring were significantly lighter at birth (P < 0.05), but there were no differences in birthweight of F2 offspring. Left ventricular weights and volumes were significantly increased (P < 0.05) in F1 and F2 restricted offspring at day 35. Left ventricular cardiomyocyte number was not different in F1 and F2 restricted offspring. At 6 months-of-age, F1 and F2 restricted offspring had elevated blood pressure (8–15 mmHg, P < 0.05). Our findings demonstrate the emergence of left ventricular hypertrophy and hypertension, with no change in cardiomyocyte number, in F1 restricted male offspring, and this was transmitted to the F2 offspring. The findings support transgenerational programming effects.
Keyword Blood pressure
Cardiomyocyte number
Growth restriction
Left ventricular hypertrophy
Transgenerational transmission
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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