Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state

Huang, Lili, Tan, Hwee Y., Fogarty, Matthew J., Andrews, Zane B., Veldhuis, Johannes D., Herzog, Herbert, Steyn, Frederik J. and Chen, Chen (2014) Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state. Journal of Neuroscience, 34 49: 16309-16319. doi:10.1523/JNEUROSCI.4622-13.2014

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Author Huang, Lili
Tan, Hwee Y.
Fogarty, Matthew J.
Andrews, Zane B.
Veldhuis, Johannes D.
Herzog, Herbert
Steyn, Frederik J.
Chen, Chen
Title Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
0270-6474
Publication date 2014-12-03
Year available 2014
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4622-13.2014
Open Access Status File (Publisher version)
Volume 34
Issue 49
Start page 16309
End page 16319
Total pages 11
Place of publication Washington, DC United States
Publisher Society for Neuroscience
Collection year 2015
Language eng
Formatted abstract
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the mechanism through which endogenous NPY modulates GH release remains unknown. Moreover, conclusive evidence demonstrating a role for NPY and Y-receptors in regulating the endogenous pulsatile release of GH does not exist. We used genetically modified mice (germline Npy, Y1, and Y2 receptor knock-out mice) to assess pulsatile GH secretion under both fed and fasting conditions. Deletion of NPY did not impact fed GH release; however, it reversed the fasting-induced suppression of pulsatile GH secretion. The recovery of GH secretion was associated with a reduction in hypothalamic somatotropin release inhibiting factor (Srif; somatostatin) mRNA expression. Moreover, observations revealed a differential role for Y1 and Y2 receptors, wherein the postsynaptic Y1 receptor suppresses GH secretion in fasting. In contrast, the presynaptic Y2 receptor maintains normal GH output under long-term ad libitum-fed conditions. These data demonstrate an integrated neural circuit that modulates GH release relative to food intake, and provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states.
Keyword Fasting
Feeding
Growth hormone
NPY
NPY-receptors
Somatostatin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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