Language changes coincide with motor and fMRI changes following upper extremity motor therapy for hemiparesis: a brief report

Harnish, Stacy, Meinzer, Marcus, Trinastic, Jonathan, Fitzgerald, David and Page, Stephen (2014) Language changes coincide with motor and fMRI changes following upper extremity motor therapy for hemiparesis: a brief report. Brain Imaging and Behavior, 8 3: 370-377. doi:10.1007/s11682-011-9139-y


Author Harnish, Stacy
Meinzer, Marcus
Trinastic, Jonathan
Fitzgerald, David
Page, Stephen
Title Language changes coincide with motor and fMRI changes following upper extremity motor therapy for hemiparesis: a brief report
Journal name Brain Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7565
1931-7557
Publication date 2014-09
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s11682-011-9139-y
Open Access Status
Volume 8
Issue 3
Start page 370
End page 377
Total pages 8
Place of publication New York, USA
Publisher Springer
Collection year 2015
Language eng
Formatted abstract
To formally assess changes in language, affected UE movement, and motor functional activation changes via functional magnetic resonance imaging (fMRI) following participation in motor therapy without any accompanying language intervention. Pre-post case series. Five subjects with stroke exhibiting chronic, stable UE hemiparesis. The upper extremity section of the Fugl-Meyer (FM), the Western Aphasia Battery (WAB), and functional magnetic resonance imaging (fMRI), administered during performance of an affected UE motor task. All subjects were administered six weeks of repetitive task specific training (RTP), performed for approximately 2.5 hours per day, split into two sessions. For the first four weeks of the intervention period, RTP was administered every weekday, whereas, for the subsequent two weeks, RTP was administered 3 days/week. Epidural cortical stimulation was co-administered with the RTP via an electrode array and implanted pulse generator. For all sessions, one subject worked with a single therapist. Four weeks before and four weeks after the intervention period, all subjects were administered the FM, WAB, and fMRI. Three of the subjects exhibited clinically significant language changes on the WAB. These individuals exhibited the largest motor changes as measured by the FM. Functional MRI revealed distinct motor activation patterns in these subjects, characterized by more strongly right lateralized focal BOLD activity or a shift in activation toward the right hemisphere. Language changes appear to co-occur with motor changes after UE RTP. Understanding the underlying mechanisms of these findings may lead to more efficient and synergistic rehabilitative therapy delivery.
Keyword Hemiplegia
Neuroimaging
Occupational therapy
Speech therapy
Stroke
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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