Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method

Ng, JC, JohnsonD, ImrayP, ChiswellB and MooreMR (1998) Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method. Analyst, 123 5: 929-933. doi:10.1039/a707726b

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Author Ng, JC
JohnsonD
ImrayP
ChiswellB
MooreMR
Title Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method
Journal name Analyst   Check publisher's open access policy
ISSN 0003-2654
Publication date 1998
Sub-type Article (original research)
DOI 10.1039/a707726b
Open Access Status File (Publisher version)
Volume 123
Issue 5
Start page 929
End page 933
Total pages 5
Language eng
Abstract A hydride cold-trapping technique was developed and optimised for the measurement of urinary arsenic metabolites. The analytical precision of the method was found to be 6.1, 4.0 and 4.8% (n = 5) for inorganic arsenic (As-i), monomethylarsonate (MMA) and dimethylarsinate (DMA), respectively, with recoveries close to 100%, The detection limits were 1.0, 1.3 and 3 ng for As-i, MMA and DMA, respectively. The method was then used to analyse urine samples obtained from three groups of workers for occupational exposure in three companies where copper chrome arsenate was used for timber treatment. The results were compared with those for a normal control group of laboratory workers. Arsenic and its metabolites were also measured in experimental rats given 5 mg As kg(-1) body mass by oral gavage in the form of sodium arsenite, calcium arsenite or sodium arsenate. Occupational workers showed a significantly higher excretion of As-i, Up to two fold increases of urinary As-i excretion in rats compared with control rats were also observed in animals dosed with various forms of arsenicals. The method is suitable for the measurement of arsenic metabolites in urine of both humans and experimental animals.
Keyword Chemistry, Analytical
Arsenic, Speciation
Monomethylarsonate
Dimethylarsinate
Arsenic Methylation
Urinary Metabolite
Hydride Generation Atomic Absorption Spectrometry
Atomic-absorption Spectrometry
Transition-metal Interferences
Nanogram Amounts
Generation
Selenium
Mechanisms
Nickel
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Mon, 13 Aug 2007, 10:27:41 EST