Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification—a retrospective analysis

Orchard, Gregory R., Paratz, Jennifer D., Blot, Stijn and Roberts, Jason A. (2014) Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification—a retrospective analysis. Journal of Burn Care and Research, 36 4: 465-470. doi:10.1097/BCR.0000000000000123


Author Orchard, Gregory R.
Paratz, Jennifer D.
Blot, Stijn
Roberts, Jason A.
Title Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification—a retrospective analysis
Journal name Journal of Burn Care and Research   Check publisher's open access policy
ISSN 1559-0488
1559-047X
Publication date 2014-12-18
Year available 2014
Sub-type Article (original research)
DOI 10.1097/BCR.0000000000000123
Open Access Status
Volume 36
Issue 4
Start page 465
End page 470
Total pages 6
Place of publication Philadelphia PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2015
Language eng
Abstract The aims of this study was to identify the risk factors for developing heterotopic ossification in patients with burns injuries and second, to review the outcomes associated with the treatment disodium etidronate. Patients with heterotopic ossification were identified using the burns unit computer database. The control group was the patients that were the next admission, post admission of patient that subsequently developed heterotopic ossification. Demographic and clinical data were collected. Univariate and multivariate techniques were used to identify risk factors for heterotopic ossification. We reviewed 337 patients admitted over a 5-year period and identified 19 patients with heterotopic ossification (5.6%). A further 19 burn injury patients were included as controls. Heterotopic ossification developed clinically and radiologically after a median time of 37 days (interquartile range [IQR], 30-40) and 49 days (IQR, 38-118), respectively. In univariate analysis, heterotopic ossification was associated with a greater %TBSA, inhalation injury, use of mechanical ventilation, number of surgical procedures, sepsis, and longer time to active movement. In a multivariate analysis that adjusted for severity of burn injury by means of the Belgian Outcome in Burn Injury score, time to active movement was recognized as an independent risk factor for heterotopic ossification (odds ratio 1.48, 95% confidence interval 1.09-2.01). Elevations in serum calcium concentrations were the only observed adverse effects for disodium etidonrate. This study has demonstrated that %TBSA, inhalation injury, and the need for ventilatory support and the use of multiple surgical procedures are predictive of the development of heterotopic ossification.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 18 Dec 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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