Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes

Coughlan, M. T., Forbes, J. M. and Cooper, M. E. (2007). Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes. In: 5th Hyonam-Kidney-Laboratory-International-Diabetes Symposium, Seoul South Korea, (S54-S60). Feb 02-03, 2007. doi:10.1038/sj.ki.5002387


Author Coughlan, M. T.
Forbes, J. M.
Cooper, M. E.
Title of paper Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes
Conference name 5th Hyonam-Kidney-Laboratory-International-Diabetes Symposium
Conference location Seoul South Korea
Conference dates Feb 02-03, 2007
Journal name Kidney International   Check publisher's open access policy
Publication Year 2007
Sub-type Fully published paper
DOI 10.1038/sj.ki.5002387
ISSN 0085-2538
Volume 72
Issue SUPPL. 106
Start page S54
End page S60
Total pages 1
Language eng
Abstract/Summary The biochemical process of advanced glycation appears to play a central role in the development and progression of diabetic vascular complications. A number of strategies to influence this pathway have been designed, one of which involves the putative advanced glycation end-product (AGE) crosslink breaker, alagebrium which has been shown in in vitro studies to cleave preformed AGE crosslinks. This agent has been studied in various models of diabetic complications and has been shown to attenuate diabetic renal disease, cardiac dysfunction, and atherosclerosis. In addition to the ability of alagebrium to reduce tissue levels of AGEs, this drug appears to inhibit activation of certain protein kinase C isoforms. Planned clinical studies in diabetic subjects at risk of complications should assist in determining the role of alagebrium in the prevention, retardation, and reversal of diabetic micro- and macrovascular disease.
Subjects 2727 Nephrology
Keyword Advanced glycation end products
Alagebrium
Diabetes complications
Diabetic nephropathy
Oxidative stress
Protein kinase C
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: Scopus Import
 
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Created: Mon, 05 Jan 2015, 12:47:13 EST by Ms Kate Rowe