Influenza virus and endothelial cells: a species specific relationship

Short, Kirsty R., Kroeze, Edwin J. B. Veldhuis, Reperant, Leslie A., Richard, Mathilde and Kuiken, Thijs (2014) Influenza virus and endothelial cells: a species specific relationship. Frontiers in Microbiology, 5 DEC: 653.1-653.11. doi:10.3389/fmicb.2014.00653


Author Short, Kirsty R.
Kroeze, Edwin J. B. Veldhuis
Reperant, Leslie A.
Richard, Mathilde
Kuiken, Thijs
Title Influenza virus and endothelial cells: a species specific relationship
Journal name Frontiers in Microbiology   Check publisher's open access policy
ISSN 1664-302X
Publication date 2014-12-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fmicb.2014.00653
Open Access Status DOI
Volume 5
Issue DEC
Start page 653.1
End page 653.11
Total pages 11
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2015
Language eng
Abstract Influenza A virus (IAV) infection is an important cause of respiratory disease in humans. The original reservoirs of IAV are wild waterfowl and shorebirds, where virus infection causes limited, if any, disease. Both in humans and in wild waterbirds, epithelial cells are the main target of infection. However, influenza virus can spread from wild bird species to terrestrial poultry. Here, the virus can evolve into highly pathogenic avian influenza (HPAI). Part of this evolution involves increased viral tropism for endothelial cells. HPAI virus infections not only cause severe disease in chickens and other terrestrial poultry species but can also spread to humans and back to wild bird populations. Here, we review the role of the endothelium in the pathogenesis of influenza virus infection in wild birds, terrestrial poultry and humans with a particular focus on HPAI viruses. We demonstrate that whilst the endothelium is an important target of virus infection in terrestrial poultry and some wild bird species, in humans the endothelium is more important in controlling the local inflammatory milieu. Thus, the endothelium plays an important, but species-specific, role in the pathogenesis of influenza virus infection.
Keyword Influenza virus
Endothelial cells
Highly pathogenic avian influenza
Zoonotic infection
Poultry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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Created: Tue, 30 Dec 2014, 23:37:50 EST by Kirsty Short on behalf of School of Biomedical Sciences