Nasality in Friedreich ataxia

Poole, Matthew L, Wee, Jessica S, Folker, Joanne E, Corben, Louise A, Delatycki, Martin B and Vogel, Adam P (2015) Nasality in Friedreich ataxia. Clinical Linguistics and Phonetics, 29 1: 46-58. doi:10.3109/02699206.2014.954734


Author Poole, Matthew L
Wee, Jessica S
Folker, Joanne E
Corben, Louise A
Delatycki, Martin B
Vogel, Adam P
Title Nasality in Friedreich ataxia
Journal name Clinical Linguistics and Phonetics   Check publisher's open access policy
ISSN 1464-5076
0269-9206
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.3109/02699206.2014.954734
Volume 29
Issue 1
Start page 46
End page 58
Total pages 13
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2016
Language eng
Formatted abstract
Perceptual speech research in Friedreich ataxia (FRDA) has identified altered nasality as a key component of the dysarthria profile, however the incidence and severity of abnormal nasality remains unknown. Utilizing objective and perceptual methods, data on the relationship between resonance, disease duration, severity, age of onset and genetic profiles were collated. Thirty-seven participants with FRDA and 24 healthy controls provided contemporaneous speech samples for perceptual analysis, and single word samples for acoustic analysis. A subset of participants (eight participants with FRDA and eight controls) underwent nasometry assessment. Twenty-seven participants with FRDA presented with hypernasality and five with hyponasality on perceptual assessment. Acoustic analysis revealed participants with FRDA had greater nasality than controls (p < 0.05). Perceptual ratings of hypernasality correlated with GAA2 repeat length (ρ = 0.37, p = 0.03). Findings highlight the variability of nasality in FRDA, potentially reflecting variation in the neuropathological profile. Data also suggest the influence of genetic profiles on nasality.
Keyword Ataxia
Dysarthria
Hypernasality
Hyponasality
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Health and Rehabilitation Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 30 Dec 2014, 10:17:42 EST by System User on behalf of Scholarly Communication and Digitisation Service